|
KMID : 0624620140470060299
|
|
BMB Reports
2014 Volume.47 No. 6 p.299 ~ p.310
|
|
|
Cohesin gene mutations in tumorigenesis: from discovery to clinical significance
|
|
Solomon David A.
Kim Jung-Sik
Waldman Todd
|
|
|
Abstract
|
|
|
|
Cohesin is a multi-protein complex composed of four core subunits (SMC1A, SMC3, RAD21, and either STAG1 or STAG2) that is responsible for the cohesion of sister chromatids following DNA replication until its cleavage during mitosis thereby enabling faithful segregation of sister chromatids into two daughter cells. Recent cancer genomics analyses have discovered a high frequency of somatic mutations in the genes encoding the core cohesin subunits as well as cohesin regulatory factors (e.g. NIPBL, PDS5B, ESPL1) in a select subset of human tumors including glioblastoma, Ewing sarcoma, urothelial carcinoma, acute myeloid leukemia, and acute megakaryoblastic leukemia. Herein we review these studies including discussion of the functional significance of cohesin inactivation in tumorigenesis and potential therapeutic mechanisms to selectively target cancers harboring cohesin mutations.
|
|
|
KEYWORD
|
|
|
Acute myeloid leukemia, Aneuploidy, Bladder cancer, Chromosomal instability, Cohesin, Ewing sarcoma, Glioblastoma, Mitosis, Sister chromatid cohesion, STAG2, Urothelial carcinoma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|